What is the significance of tumor-associated macrophages in classical Hodgkin lymphoma?

Clinical Trial Highlights published on March 24, 2014
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Christian G. Steidl, MD, PhD
Assistant Professor
Department of Pathology and Laboratory Medicine
University of British Columbia
Vancouver, British Columbia
What is the significance of tumor-associated macrophages in classical Hodgkin lymphoma?
In 2010, we published a seminal study in The New England Journal of Medicine about the role of tumor-associated microphages in classical Hodgkin lymphoma. In this study, we have found for the first time a significant correlation of CD68+ cells with progression-free and overall survival. In subsequent studies including the EA2496 Intergroup trial, we have reproduced these results and could show that specifically a subset of tumor-associated macrophages, CD163+ macrophages, are correlated with progression-free and overall survival. Other groups have also validated the prognostic impact of macrophages in general and specific subsets. Again, in our NanoString study, we see a very prominent macrophage signature in the 23 genes that have been selected for the model, validating the previous findings of our group and others.
Last modified: March 24, 2014

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