What is the significance of the tumor microenvironment in classical Hodgkin lymphoma?
FAQ published on April 9, 2014
Christian G. Steidl, MD, PhD
Assistant Professor
Department of Pathology and Laboratory Medicine
University of British Columbia
Vancouver, British Columbia
Assistant Professor
Department of Pathology and Laboratory Medicine
University of British Columbia
Vancouver, British Columbia
What is the significance of the tumor microenvironment in classical Hodgkin lymphoma?
The question is what the significance of the tumor microenvironment is in classical Hodgkin lymphoma. Classical Hodgkin lymphoma is a unique lymphoma in that the malignant cells are heavily outnumbered by reactive cells in the microenvironment. Therefore, it serves as a very good paradigm to study tumor microenvironment interactions in Hodgkin lymphoma and in lymphoma in general. Using the microenvironment as a biomarker, we can learn unique biology, but we can also use the information to predict outcomes in this disease. In the literature, most of the biomarkers are at the moment related to the microenvironment because of its relative abundance compared to the malignant cells.
Last modified: April 9, 2014